Calprotectin, Feces (Referred Out)- Saskatoon
Discipline
Biochemistry
Overview
Description
- Aid in differentiation of inflammatory bowel disease (IBD) from irritable bowel syndrome (IBS) and other functional disorders of the gastrointestinal (GI) system. Aid in monitoring IBD and prediction of relapse.
Alias
- Fecal calprotectin
Specimen Information
Specimen types accepted
- Feces
Specimen collection container
- Preferred collection container: Sterile Wide Mouth Screw Cap Container
Collection procedure
Required volume
- Optimal volume: Walnut size amount (approximately 10g)
Transport and stability
- Store at 2-8°C or on an ice pack until delivered to the laboratory.
Rejection criteria
- Specimens received where the collection protocols were not followed
- Pathology and Laboratory Medicine Acceptance and Rejection Criteria
Testing Information
Relevant clinical history
- Persistent watery or bloody diarrhea
- Relevant Recent Medication History - Borderline results in fecal calprotectin may be observed in patients taking NSAIDs, aspirin, or proton-pump inhibitors. For borderline results, repeat testing in 4 to 6 weeks is suggested.
Clinical interpretation
- Calprotectin concentrations of 50.0 µg/g and lower are not suggestive of an active inflammatory process within the gastrointestinal system. For patients experiencing gastrointestinal symptoms, consider further evaluation for functional gastrointestinal disorders.
- Fecal Calprotectin is an indicator of the presence of neutrophils in stool and is not specific for IBD. Other intestinal ailments including GI infections and colorectal cancer can result in elevated concentrations of calprotectin.
Performance
Methodology
- Chemiluminescent Immunoassay (CLIA)
Days/times performed
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Maximum laboratory time
- 7 day turnaround time by testing laboratory
Other information
Forms required
Last Updated: October 18, 2024