Neuromyelitis Optica Antibodies, CSF (Referred Out) - Saskatoon
Discipline
Biochemistry
Overview
Description
- This test is only to be ordered by neurologists. If physician other than neurologist is ordering, have test approved by contacting the Biochemist on call through RUH switchboard.
- This panel includes aquaporin-4 Receptor antibodies and myelin oligodendrocyte glycoprotein (MOG) antibodies
Test ordering requirements
Forms required
- Specimen must arrive at SPH laboratory with copy of requisition
- Fill in the ‘Other tests’ location on the Miscellaneous Specimen Requisition Form #101878 or SHR Laboratory Medicine Community Laboratory Requisition Form #101064 or Acute Care Phlebotomy Requisition Form #101062
Alias
- NMO antibodies
- Aquaporin 4 antibodies
- Myelin oligodendrocyte glycoprotein (MOG) antibodies
- Devic’s Disease
Specimen Information
Specimen types accepted
- CSF
Specimen collection container
- Preferred collection container: CSF collection container
- Alternative collection container: Aliquot of CSF
Required volume
- Optimal volume: 2-3 mL CSF
- Minimum volume: 1 mL CSF
(Submitting the minimum volume makes it impossible to repeat the test or perform confirmatory/reflex testing. In some situations, a minimum volume may require a second collection.)
Testing Information
Clinical interpretation
- Result interpretation should be correlated with clinical and other laboratory findings.
Performance
Days/times performed
Availability |
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Testing site |
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Maximum laboratory time
- 5 - 7 day turnaround time by testing laboratory
Other information
Additional comments
- International consensus diagnostic criteria for neuromyelitis optica spectrum disorders (Neurology, 2015): Routine CSF testing of AQP4-IgG-Seronegative patients is not recommended but might be considered in selected seronegative cases, especially those with additional confounding serum autoantibodies that may lead to uninterpretable or false positive assay results. Cases of clinical NMO in which AQP4-IgG was detected in CSF are very rare.
- Detection of AQP4-IgG in CSF could be useful to distinguish NMO from multiple sclerosis early in the course of disease.
- CSF generally lacks the nonorgan-specific IgG autoantibodies (e. g, antinuclear, antimitochondrial, and smooth muscle) that are common in serum of patients with NMO and also with classic paraneoplastic autoimmune disorders.
Clearance required
- If physician other than neurologist is ordering, have test approved by contacting the Biochemist on call through RUH switchboard
Last Updated: October 9, 2024