Paraneoplastic Antibody Small Panel, Serum (Referred Out) - Saskatoon
Discipline
Biochemistry
Overview
Description
Testing Ordering Requirements
Forms Required
- Copy of requisition MUST accompany specimen to SPH laboratory
- Fill in the ‘Other tests’ location on the Acute Care Phlebotomy Requisition
Specimen Information
Specimen types accepted
- Serum
Specimen collection container
- Preferred Collection Container: Gold (gel)
- Alternative Collection Container: Red (non-gel)
Required volume
- Optimal Volume: 4.5 mL Full collection tube
- Minimum Volume: 1 mL serum
(Submitting the minimum volume makes it impossible to repeat the test or perform confirmatory/reflex testing. In some situations, a minimum volume may require a second collection)
Testing Information
Clinical interpretation
- Paraneoplastic syndromes are a group of rare disorders caused by an abnormal immune system response to a cancerous tumor. Patients might present symptoms including difficulty in walking or swallowing, loss of muscle tone, loss of fine motor coordination, slurred speech, memory loss, vision problems, sleep disturbances, dementia, seizures, sensory loss in the limbs, and vertigo or dizziness. The disorders are most common in patients with lung, ovarian, lymphatic or breast cancer. Neurological symptoms may develop over days or weeks prior to the tumor being discovered.
- Paraneoplastic syndromes include stiff-person syndrome, myasthenia gravis, encephalomyelitis, Lambert-Eaton myasthenic syndrome, cerebellar degeneration, limbic or brainstem encephalitis, neuromyotonia, opsoclonus, and sensory neuropathy.
Performance
Days/times performed
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Maximum laboratory time
Results Reporting
- 5 day turnaround time by testing laboratory
Other information
- Paraneoplastic Disease profile includes: 1) Amphiphysin, 2) Ri (NOVA‐1), 3) Yo, 5) Hu, 6) PNMA2 (Ma2/Ta), 7) CV2.1, 8) Recoverin, 9) SOX1, 10) Titin 11) Zic4 12) GAD65 12) Tr (DNER)
Last Updated: October 9, 2024