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Pharmacogenomics Association Testing (HLA) - Provincial

Discipline

Histocompatibility and Immunogenetics (HLA)

Overview

Description

  • Preferred collection Monday to Thursday
  • Please refer to HLA-B5701 in the Lab Medicine Test Catalogue for specific information regarding HLA-B*57:01 testing

Specimen Information

Specimen types accepted

  • Whole blood

Specimen collection container

Required volume

  • Optimal volume: 2- 4 mL lavender top tubes
  • Minimum volume: 1 mL

(Submitting the minimum volume makes it impossible to repeat the test or perform confirmatory/reflex testing. In some situations, a minimum volume may require a second collection.)

Transport and stability

  • Stable for 5 days at 4-25°c

Rejection criteria

  • Unlabeled, illegibly-labelled, mislabeled, or inadequately labelled specimens
  • Original labeling must be present and visible
  • Incomplete, inaccurate, or illegible information on the requisition
  • Discrepancies between requisition patient information and specimen label information
  • Collected by – required for all collections
  • Date and time of collection
  • Pathology and Laboratory Medicine Acceptance and Rejection Criteria

Testing Information

Relevant clinical history

  • Diagnosis
  • Recent transfusions
  • Ethnicity

Clinical interpretation

  • Strong associations have been reported between specific human leukocyte antigen (HLA) alleles and susceptibility to hypersensitivity reactions.

Performance

Methodology

  • Low and/or high resolution molecular typing (rSSO/SSP)

Days/times performed

Availability
  • Monday to Friday, except statutory holidays
Testing site
  • SPH

Maximum laboratory time

  • 21 days

Specimen retention time

  • Specimen (Extracted DNA) retained for one year.

Other information

  • Please request specific allele required
  • B15:02 HLA Carbamazepine Hypersensitivity/SJS for Asians, A31:01 HLA Carbamazepine Hypersensitivity/SJS for Caucasian, B58:01 HLA for Allopurinol Hypersensitivity
  • Forms required - HIL Test Request Form

Last Updated: July 4, 2024