Cystinuria Profile, Urine (Referred Out) - Saskatoon
Discipline
Biochemistry
Overview
Description
- Cystinuria profile is processed as part of Urine Amino Acids test. Any elevated amino acids quantitation levels will be reported.
Forms required
- Requisitions must have specific test indicated
- Miscellaneous Specimen Requisition Form #101878 or SHR Laboratory Medicine Community Laboratory Requisition Form #101064 or Acute Care Phlebotomy Requisition Form #10162
Alias
- Cystinuria
- Urine Amino Acid profile
- Cystine in Urine
Specimen Information
Specimen types accepted
- Random Urine
Specimen collection container
- Preferred collection container: Sterile Wide Mouthed Screw Cap Container(Pink top)
Required volume
- Optimal volume: 5 mL urine
- Minimum/Pediatric volume: 1 mL urine
(Submitting the minimum volume makes it impossible to repeat the test or perform confirmatory/reflex testing. In some situations, a minimum volume may require a second collection.)
Transport and stability
- Send to SPH on an ice pack.
- Freeze immediately upon receipt in the lab.
- Ship frozen to referral laboratory
Rejection criteria
- If specimen thaws it is unsuitable for analysis.
- Specimens received where the proper collection protocols were not followed
- Pathology and Laboratory Medicine Acceptance and Rejection Criteria
Testing Information
Relevant clinical history
- Family history
- Must include diagnosis and/or patient symptoms on the requisition.
- Relevant Recent Medication History - A recent medication list is relevant for clinical interpretation of results
Clinical interpretation
- Result interpretation should be correlated with clinical and other laboratory findings.
Performance
Days/times performed
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Maximum laboratory time
- 7 day turnaround time by referral laboratory
Other information
Additional comments
- Cystinuria is an inborn metabolic error caused by a defect in amino acid transport. However, presentation of cystinuria is rare in infancy, but in the second or third decade of life. Urine from affected patient may contain colorless, hexagonal cystine crystal. This disorder has a incident rate of 1 in 10,000 worldwide and accounts for 1-2% cases of nephrolithiasis and 6-8% in the pediatric population
- Urine amino acid profile of patients with cystinuria displays increased excretion of cystine, ornithine, lysine and arginine.
Last Updated: October 8, 2024