Acylcarnitine Profile Qualitative, Dried Blood Spot (Referred Out) - Saskatoon
Discipline
Biochemistry
Overview
Description
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Acylcarnitines are reported qualitatively
- Please order Acylcarnitines Quantitative (plasma) if the concentrations of acylcarnitines are needed
Test ordering requirements
Forms required
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Miscellaneous Specimen Requisition Form #101878 or SHR Laboratory Medicine Community Laboratory Requisition Form #101064 or Acute Care Phlebotomy Requisition Form #101062
- Requisitions must have specific test indicated
Alias
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Fatty Acid Oxidation Disorders
- Organic acidurias
Specimen Information
Specimen types accepted
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Whole blood
Specimen collection container
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Preferred collection container: Dark Green (Lithium Heparin) 4 mL
- Alternative collection container: Dark Green (Sodium Heparin) 4 mL
Required volume
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Optimal volume: 4 mL whole blood
- Minimum/pediatric volume: 1 mL whole blood
Transport and stability
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Whole blood must be received within 24 hours of collection
- Store whole blood at room temperature
- Neonatal Screen Card should be spotted with whole blood within 24 hours of collection
- Once spotted, the Neonatal Screen Card should be allowed to dry for 3-4 hours & shipped to referral laboratory at ambient temperature.
Rejection criteria
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Specimens received where the proper collection protocols were not followed
- Pathology and Laboratory Acceptance and Rejection Criteria
Testing Information
Relevant clinical history
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Relevant recent medication history - Valproic acid may cause falsely elevated results
Clinical interpretation
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The interpretation is based on pattern recognition
Performance
Methodology
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Available upon request
Days/times performed
| Availability |
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| Testing site |
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Maximum laboratory time
- 10 day turnaround time by referral laboratory
Other information
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The Neonatal Screen card will be spotted when whole blood received in the lab
- Acylcarnitine profile is useful to screen for several fatty acid oxidation disorders and organic academias
- Patients with fatty acid oxidation disorders and organic acidurias may present hypoglycemia, acidosis, hypotonia, seizures, and various developmental abnormalities
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Valproic acid may cause falsely elevated results
Last Updated: October 16, 2024