D Lactate, Blood (Referred Out)- Saskatoon
Discipline
Biochemistry
Overview
Description
- D-lactic acid must be specifically requested.
- It should NOT be confused with L-lactate.
- Used as an adjunct to urine D-Lactate in the diagnosis of D-lactate acidosis.
- Urine is the preferred specimen for D-lactate acidosis evaluation.
Test Ordering Requirements
Preferred Specimen Collection
- Have patient collected at a patient service center or a hospital test center, as specimen requires immediate processing
Alias
- D-lactic acid
- Lactate-D
- Lactic Acid-D
Specimen Information
Specimen types accepted
- Serum
Specimen collection container
- Preferred Collection Container: Gold (gel) 5.0mL
- Alternative Collection Container: Red (no additive) 6.0mL
Collection procedure
- Specimen must be centrifuged and serum removed from cells and frozen within 60 minutes of collection
Required volume
- Optimal Volume: 4.5 mL Full collection tube
- Minimum: 1 mL serum
Rejection criteria
- Specimens received where the collection protocols were not followed
- Pathology and Laboratory Medicine Acceptance and Rejection Criteria
Testing Information
Clinical interpretation
- Used in the work-up of d-lactic acidosis, which can be found in small bowel syndrome and in conditions of bacterial overgrowth, such as jejunoileal bypass surgery
Performance
Days/times performed
Availability |
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Testing Site |
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Maximum laboratory time
- 10 day turnaround time by testing laboratory
Other information
Additional Information
- D-lactate is produced by bacteria residing in the colon when carbohydrates are not completely absorbed in the small intestine. Most common methods for lactate do not detect D-lactate acidosis. This form of lactate should be considered only in patients with short-bowel syndromes or after other gastrointestinal surgeries resulting in “blind loops”. In addition, children with gastroenteritis may also develop the critical presentation of D-lactic acidosis.
- D-lactate is quickly excreted in urine. Thus urine is the preferred specimen for D-lactate determinations.
Last Updated: October 10, 2024